Alflutinib methanesulfonate ( AST2818;AST-2818;ASK120067 )

Catalog No. M13393 CAS No. 2130958-55-1

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Product Name

Alflutinib methanesulfonate
Note

Research use only, not for human use.
Brief Description

Alflutinib methanesulfonate (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor.
Description

Alflutinib methanesulfonate (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.Lung Cancer Phase 1 Clinical
Synonyms

AST2818;AST-2818;ASK120067
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

Cancer
Indication

Lung Cancer

CAS Number

2130958-55-1
Formula Weight

664.71
Molecular Formula

C29H35F3N8O5S
Purity

>98% (HPLC)
Solubility

DMSO : 5 mg/mL 7.52 mM
SMILES

CN(C)CCN(C)c1nc(OCC(F)(F)F)c(Nc2nccc(n2)c3cn(C)c4ccccc34)cc1NC(=O)C=C.CS(=O)(=O)O
Chemical Name

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate

1. PCT Int. Appl. (2017), WO 2017152707 A1 20170914.
2. PCT Int. Appl. (2017), WO 2017152706 A1 20170914.

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